一、会议主题

主题：慢病防治的中药药理

二、会议组织结构

主办单位

世界中医药学会联合会中药药理专业委员会

承办单位

广东药学院

广东省代谢病中西医结合研究中心

协办单位

广东省中西医结合学会代谢病专业委员会

广州市白云山和记黄埔中药有限公司

大会主席

王宁生  广州中医药大学  教授

大会执行主席

郭  姣  广东药学院院（校）长、教授

大会秘书长

刘启德  广州中医药大学  教授

三、大会内容

特别报告    6个（特邀）

专题报告    6个（邀请、从投稿中选择）

专题报告1   心脑血管疾病防治与中药药理

专题报告2   代谢性疾病防治与中药药理

专题报告3   肿瘤防治与中药药理

专题报告4   呼吸性疾病防治与中药药理

专题报告5   系统生物学与中药药理

专题报告6   中药药理研究的新技术、新方法

一般报告（壁报交流）  （从投稿中选择）

四、会议规模

本次会议规模预计为100-150人

五、会议语言

中文和英文

六、报名和摘要的截止日期

拟参会者请填写参会表（后附），并提交英文摘要（后附例文），800 字以内，按题目、作者、所属单位、目的、方法、结果、结论的顺序撰写（A4 一页以内），于2014 年10月30 日前发送至会务组邮箱icmsgdpu@163.com。

七、会议时间与地点(初定)

2014年12月5日（星期五）-7日（星期日）

广东药学院（大学城校区）学术会议中心

（具体日程见下一轮通知）

八、会议注册

境内参会人员注册费1000元/人、境外参会人员注册费200 美元/人（含12月5日欢迎晚宴、7日午餐及晚餐、茶歇、会场租用、会议指南和摘要集印刷费用等）。

往返交通和住宿费等自理。

在读研究生报到时，凭本人学生证减免50%注册费。

 

 

 

 

九、联系方式

会务组联系人

余雪：Tel：+86-15918737137

丁晨：Tel：+86-13632245091

地址：广州大学城外环东路280号 广东药学院

邮编：510006

十、其他未尽事宜可联系会议组织人员，参见第二轮会议通知。

 

 

 

世界中医药学会联合会中药药理专业委员会

                                  2014年10月14日

 

 

 

 

附件：

世界中医药学会联合会中药药理专业委员会第七届学术年会报名表

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Neuroprotection and Learning & Memory Improvement of Renshen Shouwu against neuronal injury and Vascular Dementia in 4-Vasclua occlussion transient forebrain ischemic rats and primary neuronal cultures

Li Wan^a, Zhanyuan Luo^a, Yifan Chen ^b, Juan Bin ^b , Jianping Xu ^b， Weijian Bei^a*, Jiao Guo^a

^a Guangdong TCM key laboratory against metabolic diseases, Key Unit of Modulating Liver to Treat Hyperlipemia SATCM (State Administration of Traditional Chinese Medicine), SATCM Level 3 Lab of Lipid Metabolism, Institute of Chinese Medicinal Sciences, Guangdong Pharmaceutical University, Guangzhou Higher Education Mega Centre, Guangzhou, 510006, P.R.China.

^b Neuropharmacology Department, Nanfang Medical University, Guangzhou 510515, China

^*Corresponding author  Email: 806362747@139.com

Abstract

Aim of study: The Renshen Shouwu capsule (RSSW) is a patented Traditional Chinese Medicine, which has been widely used in China for the treatment of apoplexy syndrome and memory deficiency. The effect of post-treatment with RSSW on Vascular Dementia (VD) in global cerebral ischemia-reperfusion injury rats is so far unclear, however. This study investigate the neuroprotection and therapeutic effect of Renshen Shouwu standardized extract（RSSW） on ischemic brain neuronal injury and impairment of learning and memory and Vascular Dementia (VD) in rats, and on hypoxia and amyloid β-protein（Ab）induced injury in primary neuronal culture

Material and methods: Using in vivo rat models of VD with transient global brain ischemia /reperfusion neuronal injury and the damage of learning and memory induced by four–vessel occlusion (4-VO) in SD rats, RSSW (85、170 mg kg^-1 body weight,)  and Egb761® (80 mg·kg ^-1) was administrated po for 20 days (preventively 6 d + therapeutically 14 d after 4-VO. Learning and Memory improvement was assayed using Morris water maze test of place navigation and spatial probe. Brain morphology and hippocampus neuron survival was quantified by microscope assay of puffin brain/hippocampus slice with cresyl violet stain and Nissl's stain. Primary rat neurons were cultured for hypoxia-reoxygen and A b induced injuries.

Results: Global brain ischemia/reperfusion caused hippocampus neuronal damage and Learning & Memory damage in rats. Administration of RSSW (85, 170 mg/kg) or EGB761 for 20 days was shown to significantly reduced the lesion of the insulted brain hemisphere and improved the neurological behavior of rats，and to increase the survival pyramidal neuronal density and the numbers Nissl's body in the hippocampus after transient global brain ischemia in rats，and to improve the learning and memory ability of 4-VO vascular dementia rats in dose-dependently.

In primary rat neuronal cultures, pretreatment with RSSW (1, 5 μg/ml) protected hippocampus neurons from  Ab-induced toxic neuronal injuries, and reduced hypoxia-reoxygen induced cortical neuronal death and apoptosis in a dose-dependent manner.

Conclusions: The in vivo and in vitro results suggest that RSSW showed significant protection against neuronal injury and therapeutic effect on the damage of learning and memory in the VD rats. RSSW obviously improve learning and memory ability, protects hippocampus neurons fromαβ-induced excite-toxic injury as well as cortical neurons from hypoxia-induced injury in vitro.

Keywords: Renshen Shouwu（RSSW）; neuroprotection; four–vessel occlusion；ischemia/reperfusion injury; learning and memory; vascular dementia； hypoxia